Thomas C. Jhou

This paper expands the RatGTEx resource with transcriptome-wide associations across 3,160 RNA-seq samples, identifying 7,473 gene-trait links and 144,876 QTLs for 22,599 genes.

The paper uses Genomic SEM to identify loci underlying locomotor activity in rats, finding 31 loci compared to fewer from other methods.

This study identifies a PB-CeC circuit and posterior striatal area as cooperative drivers of opioid withdrawal aversion through chemogenetic inhibition experiments.

The paper examines mu-opioid receptor (MOR) expression in VTA-projecting afferents in male mice, finding higher MOR levels in GABAergic compared to non-GABAergic afferents.

The paper genotypes Y and mitochondrial chromosomes in heterogeneous stock rats and finds no significant associations with complex traits, except for gene expression on these chromosomes.

This study shows that inhibiting the RMTg{lozenge}VTA pathway reduces cocaine seeking and has lasting effects on drug craving during abstinence.

This study identifies D2-MSN hyperactivity as a driver of antipsychotic-induced behavioral supersensitivity and its associated symptoms.

The paper identifies PnocBNST neurons in the BNST that encode rapid arousal responses to motivational stimuli and show distinct physiological and behavioral effects.

This study identifies heritable factors in rat addiction vulnerability, showing cocaine avoidance and punishment resistance are independently heritable traits.

This study shows RMTg neurons encode aversion across various stimuli and timescales, influence VTA responses, and their lesions impair aversion-related behaviors.

This study shows that cocaine self-administration reduces prelimbic cortex neuronal activity over time, and this decrease is linked to learned drug-seeking behavior.