Celine L. St. Pierre

This paper expands the RatGTEx resource with transcriptome-wide associations across 3,160 RNA-seq samples, identifying 7,473 gene-trait links and 144,876 QTLs for 22,599 genes.

The paper uses Genomic SEM to identify loci underlying locomotor activity in rats, finding 31 loci compared to fewer from other methods.

RatXcan extends transcriptome-wide association studies to rats, enabling cross-species integration of GWAS and gene expression data to identify shared genetic mechanisms of complex traits.

This study identifies genomic loci associated with cue-reactivity in rats, linking them to incentive salience and drug abuse-related traits.

AutoQTL automates QTL analysis and GWAS by applying machine learning to detect both additive and non-additive genetic effects in genetic data.

This study performs a GWAS in HS rats to identify genetic loci associated with intraocular pressure, finding three genome-wide significant loci and five candidate genes, including novel ones.

The paper simulates GWAS in rats to show that larger sample sizes lead to an exponential increase in the number of significant loci detected.

The paper investigates how genetic, epigenetic, and environmental factors influence allele-specific gene expression in mice, identifying tissue- and context-dependent patterns and inconsistent ASE biases.

The paper genotypes over 4,000 Sprague Dawley rats to characterize genetic diversity and performs GWAS on Pavlovian conditioned approach behavior, identifying 46 significant loci.

The paper identifies a network of imprinted and non-imprinted genes that propagate parent-of-origin effects on metabolic traits through epistatic interactions in mice.

The paper identifies genetic variants responsible for gene expression differences between C57BL/6 and C57BL/10 mouse substrains.

This study identifies 30 genome-wide significant QTLs for open field behaviors in rats, with 13 candidate genes linked to psychiatric disorders in humans.

The paper introduces MiniMUGA, a genotyping array for mouse genetic QC, showing it effectively discriminates strains, detects genetic constructs, and identifies sex chromosome abnormalities.

The paper uses TRAP to analyze allelic translation efficiency imbalance in mouse astrocytes, finding that some genetic variants affect ribosome occupancy independently of transcript abundance.

The paper adapts genotype-by-sequencing for HS rats to call and impute over 3.7 million SNPs with 99% concordance compared to a genotyping array.

This study investigates replication challenges in GWAS using two mouse cohorts, finding limited replication success despite similar sample sizes and population origins.

The paper identifies epistatic gene interactions underlying parent-of-origin effects on metabolic traits in mice using reciprocal crosses and tissue-specific expression analysis.

The paper uses a mouse advanced intercross line to identify genetic associations and eQTLs for traits related to human health and disease.