Author

Laura Vangeel

Rega Institute for Medical ResearchORCID 0000-0001-8820-6617Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:mouse· 1

Frequent Co-Authors

Dirk JochmansiD· 2 shared Johan H. NeytsiD· 2 shared A. Kenneth MacLeodiD· 1 shared Alpha A. LeeiD· 1 shared Andrea R. BeccariiD· 1 shared Andrea ZalianiiD· 1 shared Andrew Wells· 1 shared Angela CoronaiD· 1 shared

Activity by Year

2021-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersPharmacology & Toxicology

Dirk JochmansORCID

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2 papers

Recent·Most cited

Pharmacology & ToxicologybioRxivPreprintJun 16, 2025

Open-science discovery of DNDI-6510, a compound that addresses genotoxic and metabolic liabilities of the COVID Moonshot SARS-CoV-2 Mpro lead inhibitor

Ed Griffen, D. Fearon, Briana Lynn McGovern…·Annette von Delft

This paper describes the optimization of a SARS-CoV-2 Mpro inhibitor to address genotoxic and metabolic liabilities, leading to improved in vivo efficacy and exposure.

5 citations

mouseexperimental assay

𝕏 PostBluesky

Molecular BiologyACS Pharmacology & Translational SciencePeer-reviewedMar 11, 2021

Identification of inhibitors of SARS-CoV-2 3CL-Pro enzymatic activity using a small molecule in-vitro repurposing screen

Maria Kuzikov, Elisa Costanzi, Jeanette Reinshagen…·Andrea Zaliani

The paper identifies 62 new inhibitors of SARS-CoV-2 3CL-Pro through a compound repurposing screen and validates their activity using X-ray crystallography.

159 citationstop 1%

experimental assaydrug response / drug discovery

𝕏 PostBluesky