Author

Andrea R. Beccari

Dompé (Italy)ORCID 0000-0001-6830-2695Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Assay:protein structure· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Andrea ZalianiiD· 2 shared Carmine TalaricoiD· 2 shared Daniela IaconisiD· 2 shared Enzo TramontanoiD· 2 shared Francesca EspositoiD· 2 shared Jeanette ReinshageniD· 2 shared Maria KuzikoviD· 2 shared Markus Wolf· 2 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersMolecular Biology

Andrea ZalianiORCID

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3 papers

Recent·Most cited

Structure of human TRPM8 channel.

Sergiy S. Palchevskyy, Mariusz Czarnocki‐Cieciura, Giulio Vistoli, Silvia I. Gervasoni, Elżbieta Nowak, Andrea R. Beccari, Marcin Nowotny, Carmine Talarico

The paper presents a cryo-EM structure of the human TRPM8 channel in the closed state and analyzes its ligand interactions and conformational states.

Communications Biology · Oct 19, 2023Peer-reviewedMolecular Biology

Resolving the pharmacological redox-sensitivity of SARS-CoV-2 PLpro in drug repurposing screening enabled identification of the competitive GRL-0617 binding site inhibitor CPI-169

Maria Kuzikov, Stefano Morasso, Jeanette Reinshagen, Markus Wolf, Vittoria Monaco, Flora Cozzolino, Simona Golič Grdadolnik, Primož Šket, Janez Plavec, Daniela Iaconis, Vincenzo Summa, Francesca Esposito, Enzo Tramontano, Maria Monti, Andrea R. Beccari, , Andrea Zaliani

The paper identifies CPI-169 as a competitive inhibitor of SARS-CoV-2 PLpro that targets the same binding site as GRL-0617, through a drug repurposing screening approach that accounts for redox-sensitivity.

bioRxiv · Oct 11, 2023 · PreprintMolecular Biology

Identification of inhibitors of SARS-CoV-2 3CL-Pro enzymatic activity using a small molecule in-vitro repurposing screen

Maria Kuzikov, Elisa Costanzi, Jeanette Reinshagen, Francesca Esposito, Laura Vangeel, Markus Wolf, Bernhard Ellinger, Carsten Claussen, Gerd Geißlinger, Angela Corona, Daniela Iaconis, Carmine Talarico, Candida Manelfi, Rolando Cannalire, Giulia Rossetti, , Andrea Zaliani

The paper identifies 62 new inhibitors of SARS-CoV-2 3CL-Pro through a compound repurposing screen and validates their activity using X-ray crystallography.

ACS Pharmacology & Translational Science · Mar 11, 2021Peer-reviewedMolecular Biology