Author

Elisa Costanzi

Elettra-Sincrotrone Trieste S.C.p.A.ORCID 0000-0002-3231-232XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:drug response / drug discovery· 1 Research Focus:protein design· 1 Assay:protein sequence· 1

Frequent Co-Authors

Alice Bedwell· 1 shared Andrea R. BeccariiD· 1 shared Andrea ZalianiiD· 1 shared Angela CoronaiD· 1 shared Barbara GiabbaiiD· 1 shared Bernhard EllingeriD· 1 shared Candida ManelfiiD· 1 shared Carmine TalaricoiD· 1 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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1 shared paperBioinformatics

Alice Bedwell

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2 papers

Recent·Most cited

Fragment-based computational design of antibodies targeting structured epitopes

Mauricio Aguilar Rangel, Alice Bedwell, Elisa Costanzi, Ross J Taylor, Rosaria Russo, Gonçalo J. L. Bernardes, Stéfano Ricagno, Judith Frydman, Michele Vendruscolo, Pietro Sormanni

A fragment-based computational method designs nanobodies targeting specific epitopes with nanomolar affinities, without requiring high-resolution antigen structures.

Science Advances · Nov 11, 2022Peer-reviewedBioinformatics

Identification of inhibitors of SARS-CoV-2 3CL-Pro enzymatic activity using a small molecule in-vitro repurposing screen

Maria Kuzikov, Elisa Costanzi, Jeanette Reinshagen, Francesca Esposito, Laura Vangeel, Markus Wolf, Bernhard Ellinger, Carsten Claussen, Gerd Geißlinger, Angela Corona, Daniela Iaconis, Carmine Talarico, Candida Manelfi, Rolando Cannalire, Giulia Rossetti, , Andrea Zaliani

The paper identifies 62 new inhibitors of SARS-CoV-2 3CL-Pro through a compound repurposing screen and validates their activity using X-ray crystallography.

ACS Pharmacology & Translational Science · Mar 11, 2021Peer-reviewedMolecular Biology