Author
Van Andel InstituteORCID 0000-0001-8820-8364Unclaimed ORCID profile · follow to get notified of new preprints
4 papers
Recent·Most cited
Steven E. Pierce, Edwin J. C. Van der Schans, Elizabeth Ensink, Gerhard A. Coetzee
The paper examines gene expression asymmetry in Parkinson's Disease, finding that CCT and BEX gene expression levels vary between hemispheres and correlate with symptom onset side.
Jordan D Prahl, Steven E. Pierce, Edwin J. C. Van der Schans…·Trevor Tyson
This study investigates the risk mechanism of rs356182, a PD risk SNP near SNCA, by generating CRISPR-Cas9 lesions in LUHMES cells and observing effects on neuronal differentiation and axonogenesis.
Lee L. Marshall, Bryan A. Killinger, Elizabeth Ensink…·Viviane Labrie
The paper identifies increased TET2 expression as a driver of epigenetic dysregulation in Parkinson’s disease neurons and shows that reducing Tet2 activity is neuroprotective in mice.
Alix Booms, Steven E. Pierce, Gerhard A. Coetzee
The paper identifies functional SNPs in microglia associated with Parkinson's disease risk, highlighting autophagy and lysosomal genes as key candidates for further study.