Juozas Gordevičius

This study identifies distinct metabolic signatures in stable and progressive IPF/ILD by integrating HRCT scores with metabolomic profiling.

The paper examines alpha-synuclein aggregation and molecular changes in appendix tissues from synucleinopathy patients compared to controls.

This study profiles DNA methylation in COVID-19 patients and finds hypomethylation linked to neurological pathways in severe cases.

The paper identifies that Tet2 loss promotes ciliogenesis and reduces α-synuclein pathology in Parkinson's disease models.

This study shows that OSKM gene therapy in old rats improves spatial learning and memory, reduces epigenetic age, and reverses age-related DNA methylation changes in the hippocampus.

This study identifies up-regulation of human endogenous retrovirus (HERV) transcripts in Parkinson's disease (PD) across multiple tissues and blood, linking TE activation to PD pathogenesis and potential treatment monitoring.

This study shows that young porcine plasma treatment reduces epigenetic age in multiple rat organs and improves physiological function.

aPEAR provides an R package for automated visualization of pathway enrichment networks by clustering similar pathways into meaningful biological themes.

This study shows that young rat plasma reduces DNA methylation age, extends lifespan, and improves health in old rats.

Rapamycin treatment during early life extends lifespan and healthspan in mice and Daphnia magna by slowing development and delaying aging.

The paper identifies increased TET2 expression as a driver of epigenetic dysregulation in Parkinson’s disease neurons and shows that reducing Tet2 activity is neuroprotective in mice.