Jiyan Ma

This study shows that reducing CDK14 genetically or pharmacologically decreases alpha-synuclein pathology and improves symptoms in Parkinson's disease models.

This study shows that α-synuclein fibrils injected into mouse forebrain cause regional pathology, early neuronal degeneration, and cognitive deficits resembling Lewy body diseases.

This study shows that T cells reduce phosphorylated α-synuclein pathology in a mouse model of α-synucleinopathy.

The paper tests if inhibiting the mitochondrial pyruvate carrier reduces synucleinopathy in PD models but finds no effect on Syn aggregation or neurodegeneration.

The paper identifies increased TET2 expression as a driver of epigenetic dysregulation in Parkinson’s disease neurons and shows that reducing Tet2 activity is neuroprotective in mice.

This study shows that lowering prion protein expression with ASOs is effective in treating prion disease across different strains, treatment times, and endpoints.

This study shows alpha-synuclein is required for interferon-stimulated gene expression in neurons during RNA virus infection and links it to phosphorylated S129-asyn pathology.

This study shows that loss of one Engrailed1 allele in mice increases α-synuclein aggregation after PFF injection, suggesting a role for En1 in PD pathology.