David R. McClay

This study identifies Evi1 as a critical mediator between Nodal and Delta-Notch signaling in sea urchin mesoderm development, showing its role in activating Notch135 and mesodermal differentiation.

The paper uses single-cell RNA sequencing to compare embryonic development in two sea urchin species, identifying evolutionary changes in cell fate specification and signaling.

The paper analyzes single-cell RNA-seq data from sea urchin development to compare larval and adult body plan formation, identifying regulatory gene differences and cell type changes.

This paper demonstrates the use of DsiRNA for functional studies in sea urchin embryos, showing its effectiveness in knocking down genes and analyzing Nodal signaling gradients.

The paper uses scRNA-seq and computational methods to study developmental trajectories and gene regulatory networks in sea urchin embryos, revealing lineage diversification and timing differences between species.

This paper constructs the first formal GRN for Heliocidaris erythrogramma, showing its developmental GRN differs significantly from ancestral sea urchins, suggesting selection over constraint in GRN conservation.