Brennan D. McDonald

The paper shows that conserved motif vocabularies constrain genome access in cell type evolution across species.

The paper identifies two lineage-committed progenitors in the developing brain that generate forebrain/midbrain and hindbrain regions, and demonstrates their distinct chromatin landscapes and differentiation potential.

The paper analyzes single-cell RNA-seq data from sea urchin development to compare larval and adult body plan formation, identifying regulatory gene differences and cell type changes.

The paper investigates how somatic Transformer and sex chromosome karyotype pathways regulate gene expression during Drosophila gonad development, showing their combined and exclusive effects on germ cell development.