Salil A. Lachke

The paper maps CELF1-RNA interactions in mice lenses, showing CELF1 represses target mRNAs to regulate lens development and prevent cataracts.

The paper identifies abundant RNA-binding proteins in mouse lenses and characterizes their interactions with crystallin and β-actin mRNAs using proteomic, transcriptomic, and imaging techniques.

The paper investigates the role of miR-26 in lens development and finds that its deficiency leads to adult-onset cataract through transcriptome alterations.

The paper creates a single-cell multiomic atlas of lens development, identifying regulatory mechanisms and cataract-linked networks through snRNA-seq, snATAC-seq, and CUT&RUN-seq.

This study identifies 54 new genetic risk loci for cataract through a multiethnic GWAS meta-analysis and finds sex-specific effects and gene expression relevance in mouse models.

The paper develops a framework to analyze subtype-specific and shared genetic effects in orofacial clefting and applies it to identify loci associated with different subtypes.