Katia Del Rio‐Tsonis

This study shows EphA3 promotes directional retinal axon growth by modulating EphA4 signaling and membrane cholesterol, enhancing extension persistence and turning behavior.

This study optimizes HCR-FISH for spatial transcript detection in Pleurodeles waltl eyes, enabling validation of gene expression patterns in regenerative tissues.

The paper identifies a developmental wave of programmed ganglion cell death in human retinal organoids, showing it occurs via the extrinsic apoptotic pathway.

This study shows that macrophages are essential for lens regeneration in newts by reducing fibrosis, modulating inflammation, and balancing cell proliferation and apoptosis.

The paper creates a single-cell multiomic atlas of lens development, identifying regulatory mechanisms and cataract-linked networks through snRNA-seq, snATAC-seq, and CUT&RUN-seq.

This study shows that metabolic states, particularly glycolysis and oxidative metabolism, influence RPE cell fate decisions during regeneration.

This study examines age-related changes in lens regeneration in newts, finding that while regenerative capacity persists, aging slows the regeneration kinetics due to delayed cell cycle re-entry and ECM clearance.

This study identifies FGF2-driven gene expression changes in embryonic chicken RPE reprogramming, highlighting MAPK signaling and EMT processes.

This study identifies DNA demethylation as a key driver of chick retina regeneration through RPE reprogramming, with TET3 playing a critical role in this process.

The paper describes a CRISPR/Cas9 strategy to generate a hiPSC line with fluorescent reporters for three retinal cell types, enabling real-time monitoring during organoid development.