Jared A. Tangeman

This study optimizes HCR-FISH for spatial transcript detection in Pleurodeles waltl eyes, enabling validation of gene expression patterns in regenerative tissues.

The paper reconstructs the evolutionary origins of retinal amacrine cell diversity using transcriptomic data from 24 vertebrate species, identifying 42 orthologous cell types and suggesting a hybrid precursor origin.

This study investigates the role of Sox8 and Sox9 in retinal Muller glia differentiation and nuclear positioning using genetic and single-cell multiomic approaches.

The paper identifies conserved and species-specific aging mechanisms in retinal cells across zebrafish, mice, and humans using single-cell multi-omics analyses.

This study shows that macrophages are essential for lens regeneration in newts by reducing fibrosis, modulating inflammation, and balancing cell proliferation and apoptosis.

The paper investigates the role of miR-26 in lens development and finds that its deficiency leads to adult-onset cataract through transcriptome alterations.

The paper creates a single-cell multiomic atlas of lens development, identifying regulatory mechanisms and cataract-linked networks through snRNA-seq, snATAC-seq, and CUT&RUN-seq.

This study shows that metabolic states, particularly glycolysis and oxidative metabolism, influence RPE cell fate decisions during regeneration.

This study identifies FGF2-driven gene expression changes in embryonic chicken RPE reprogramming, highlighting MAPK signaling and EMT processes.

This study identifies DNA demethylation as a key driver of chick retina regeneration through RPE reprogramming, with TET3 playing a critical role in this process.