Byron Lee

Loss of KDM6A-mediated genomic instability and metabolic reprogramming differentially regulates responses to immune checkpoint therapy and chemotherapy in bladder cancer.

This study shows KDM6A mutations in bladder cancer improve response to immune checkpoint therapy but worsen chemotherapy outcomes through effects on DNA repair and metabolic reprogramming.

A poly(A) isoform-aware single-cell and spatial atlas defines fibroblast niches in the human bladder

The paper creates a poly(A) isoform-aware single-cell and spatial atlas of the human bladder, identifying fibroblast niches and their spatial relationships.

Single Cell RNA-sequencing of BCG naive and recurrent non-muscle invasive bladder cancer reveals a CD6/ALCAM mediated immune-suppressive pathway

This study uses single-cell RNA sequencing to identify a CD6/ALCAM-mediated immune-suppressive pathway in recurrent NMIBC, suggesting CD6 as a potential therapeutic target.

Alternative polyadenylation regulates human urothelial differentiation

The paper investigates how alternative polyadenylation (APA) regulates urothelial differentiation using single-cell RNA-seq and spatial imaging, showing APA's role in shaping cell state-specific polyadenylation sites and transcriptome diversity.

Ureter single-cell and spatial mapping reveal cell types, architecture, and signaling networks

The paper maps cell types, architecture, and signaling networks in the human ureter using single-cell and spatial transcriptomics to inform tissue engineering strategies.