Alternative polyadenylation regulates human urothelial differentiation
N.T. Le, Surbhi Sona, Briana A. Santo, Robert Allen Schweickart, Veena Kochat, William I. Padron, Kunal Rai, Shih‐Han Lee, Joo Mi Yi, Oliver Wessely, Byron Lee, Angela H. Ting
The paper investigates how alternative polyadenylation (APA) regulates urothelial differentiation using single-cell RNA-seq and spatial imaging, showing APA's role in shaping cell state-specific polyadenylation sites and transcriptome diversity.
bioRxiv · Mar 3, 2025 · PreprintSystems Biology