Author

Yi Hua Chen

Whitehead Institute for Biomedical ResearchORCID 0000-0001-8864-8298Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:database / resource· 1 Approach:machine learning (classical)· 1

Frequent Co-Authors

Jonathan S. WeissmaniD· 2 shared Adam S Zhang· 1 shared Anders S. HanseniD· 1 shared André C. MichaelisiD· 1 shared Benjamin E. GewurziD· 1 shared Christian Pensl· 1 shared Christina J. Zhang· 1 shared Edwin N. NeumanniD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersCell Biology

Jonathan S. WeissmanORCID

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2 papers

Recent·Most cited

Cell BiologybioRxivPreprintSep 28, 2026

Failure to release from the ER translocon induces 60S ribosome degradation

Zebulon G. Levine, Stuti Khandwala, Christina J. Zhang…·Jonathan S. Weissman

The paper identifies a cell-state-dependent pathway for degrading ER-retained 60S ribosomal subunits through UFMylation loss and the action of TLSD1.

DOI 10.64898/2026.09.26.754687

humanproteomics

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Systems BiologybioRxivPreprintAug 24, 2026

✦ In-depth digest

The diverse functions of viral microproteins

Yi Hua Chen, Louisa Grauvogel, Adam S Zhang…·Jonathan S. Weissman

A >50,000-element viral smORF library screened by growth, MHC-I, ER stress, Perturb-seq and mass spectrometry yields >2,000 active microproteins and shows EBV BNLF2b inhibits PKA by mimicry.

1 citation

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