Louisa Grauvogel

The paper introduces the ZenoTOF 8600 system, which enhances proteomics by increasing ion flux and improving precursor identification and quantification in DIA mode.

The paper identifies resilience factors in aged mice using a genome-scale ORF screen, finding NKX2-5 variants that restore vision and reduce frailty.

The paper shows that enhanced gene activation in specific LUBAC mutants leads to cell death and lethal lung fibrosis, revealing gene activation as a root cause of inflammatory disease.

A >50,000-element viral smORF library screened by growth, MHC-I, ER stress, Perturb-seq and mass spectrometry yields >2,000 active microproteins and shows EBV BNLF2b inhibits PKA by mimicry.

HIP-MS is an automated platform for high-throughput interactome profiling that improves sensitivity and throughput compared to traditional AE-MS methods.

This study shows that cardiomyocyte PGC-1α is essential for cardiac adaptation to endurance exercise by suppressing GDF15 and preventing cardiac atrophy in mice.