The diverse functions of viral microproteins
Yi Hua Chen, Louisa Grauvogel, Adam S Zhang, André C. Michaelis, Tim Heymann, Elisabeth Zollbrecht, Paulina Engel, Christian Pensl, Kathryn E. Yost, Wesley Suen, Sumita Sinha, Edwin N. Neumann, Stephen Joseph Elledge, Karl‐Peter Hopfner, Benjamin E. Gewurz, , Jonathan S. Weissman
A >50,000-element viral smORF library screened by growth, MHC-I, ER stress, Perturb-seq and mass spectrometry yields >2,000 active microproteins and shows EBV BNLF2b inhibits PKA by mimicry.
bioRxiv · Aug 24, 2026 · PreprintSystems Biology✦ In-depth digest