André C. Michaelis

A >50,000-element viral smORF library screened by growth, MHC-I, ER stress, Perturb-seq and mass spectrometry yields >2,000 active microproteins and shows EBV BNLF2b inhibits PKA by mimicry.

HIP-MS is an automated platform for high-throughput interactome profiling that improves sensitivity and throughput compared to traditional AE-MS methods.

The paper develops a high-throughput AP-MS method to map a comprehensive yeast interactome, doubling the number of proteins and tripling reliable interactions.

The paper introduces directLFQ, a label-free quantification method that scales linearly with sample numbers, enabling rapid analysis of large proteomics datasets.

The paper introduces a DIA-based systems biology workflow for high-throughput proteome analysis in yeast, revealing novel E3 ligase responses to metabolic shifts.