Shirin Doroudgar

The paper examines the relationship between the ER and SR in cardiac myocytes, finding that the SR becomes the primary site of protein synthesis in adult cells, while the ER retains specialized functions.

This study shows that the unfolded protein response declines with age in the heart, leading to protein misfolding and cardiac dysfunction.

The paper identifies Cand2 as an mTORC1-regulated gene that promotes adverse cardiac remodeling when overexpressed, and shows its deletion protects the myocardium.

The paper compares transcriptome and translatome networks in cardiac remodeling to identify differences in gene regulation and functional modules.