Tobias Jakobi

Continuous Integration and Software Quality in Scientific Software: A Large-Scale Empirical Analysis of GitHub Repositories

This study analyzes GitHub repositories to show that continuous integration and testing improve software quality and academic impact in scientific software.

ZEB1 Is a Key Regulator of Cardiomyocyte Structure and Function

This study investigates ZEB1's role in cardiomyocyte structure and function, finding that its deletion causes sarcomere damage, mitochondrial dysfunction, and dedifferentiation, particularly in females.

Extending scope and power of circular RNA researchwith circtools 2.0

The paper introduces circtools 2.0, an enhanced software for circRNA detection and analysis, with new features for improved detection, probe design, conservation analysis, and support for Oxford Nanopore sequencing.

Large-scale benchmarking of circRNA detection tools reveals large differences in sensitivity but not in precision

The paper benchmarks 16 circRNA detection tools across three human cell types, finding large differences in sensitivity but consistent precision, and recommends tool combinations for improved detection.

Ythdf2 regulates cardiac remodeling through its m6A-mRNA target transcripts

This study shows that Ythdf2, an m6A reader protein, regulates cardiac function by controlling gene expression through its target transcripts, leading to cardiac remodeling in heart failure models.

Transient inhibition of translation improves long-term cardiac function after ischemia/reperfusion by attenuating the inflammatory response

This study shows that temporarily inhibiting protein translation after heart attack reduces inflammation and improves long-term heart function by targeting the mTORC1-4EBP1-eIF4F pathway.

Age-related decline of the unfolded protein response in the heart promotes protein misfolding and cardiac pathology

This study shows that the unfolded protein response declines with age in the heart, leading to protein misfolding and cardiac dysfunction.