Amber Delmas Eliason

COPD Preferentially Disrupts Constitutive Redox Support Relative to Inducible Antioxidant Defense

The paper identifies a cell-selective loss of constitutive redox support in COPD, with reduced PGC-1 target-program output in fibroblasts.

8-Oxoguanine transcriptional miscoding can transiently reproduce PAH-associated premature-stop transcripts

The paper shows that 8-oxoguanine can create premature-stop transcripts in PAH genes, mimicking pathogenic variants without DNA mutation.

Disease-associated protein states accessible to 8-oxoguanine transcriptional miscoding without genomic mutation

The paper identifies disease-associated protein states caused by 8-oxoG transcriptional miscoding, showing 5.7% of pathogenic missense variants can arise without genomic mutation.

Ileitis abolishes tolerogenic functions of the enterohepatic bile acid pool

The paper shows that ileitis disrupts bile acid (BA) pool balance, altering immune regulation by affecting BA receptor interactions and Th17 cell function.

Accelerated plastic aging in suspension (APAS): A simple, reproducible approach for the generation of model micro- and nanoplastics through simulated environmental forces

The paper introduces APAS, a method to generate environmentally relevant micro- and nanoplastics by simulating natural aging processes, and shows its ability to produce complex particles with physicochemical properties similar to real-world MNPs.

Quantifying forms and functions of intestinal bile acid pools in mice

The paper quantifies ileal bile acid pools in mice and shows that Asbt-mediated transport dominates their size and composition, with loss of Asbt reducing pool size and altering transcriptional responses.