GeneticsbioRxivPreprint
Genetic inhibition of PCSK9, atherogenic lipoprotein concentrations, and calcific aortic valve stenosis
Nicolas Perrot, Donato Moschetta, S. Matthijs Boekholdt…·Benoît J. Arsenault
This study shows genetic inhibition of PCSK9 lowers lipoprotein levels and reduces risk of CAD and CAVS, with PCSK9 present in calcified aortic valves and induced by oxidative stress.
DOI 10.1101/560458