Genetic inhibition of PCSK9, atherogenic lipoprotein concentrations, and calcific aortic valve stenosis
Nicolas Perrot, Donato Moschetta, S. Matthijs Boekholdt, Vincenza Valerio, Andreas Martinsson, Romain Capoulade, Elvira Mass, Marie-Annick A Clavel, Nicholas J. Wareham, Christian Dina C, Hao Yu Chen, James C. Engert, George Thanassoulis, Patrick Mathieu, Yohan Bossé, , Benoît J. Arsenault
This study shows genetic inhibition of PCSK9 lowers lipoprotein levels and reduces risk of CAD and CAVS, with PCSK9 present in calcified aortic valves and induced by oxidative stress.
bioRxiv · Mar 1, 2019 · PreprintGenetics