S. Matthijs Boekholdt

Systemic inflammation is a minor contributor to remnant cholesterol atherogenicity

This study examines the relationship between remnant cholesterol, systemic inflammation, and cardiovascular risk in a cohort, finding that remnant cholesterol is more strongly associated with MACE than LDL-C, with some mediation by inflammation.

Long-Term Exposure to Elevated Lipoprotein(a) Levels, Parental Lifespan and Risk of Mortality

This study investigates the association between elevated Lp(a) levels, parental lifespan, and long-term mortality risk using genetic and observational data.

Genetic inhibition of PCSK9, atherogenic lipoprotein concentrations, and calcific aortic valve stenosis

This study shows genetic inhibition of PCSK9 lowers lipoprotein levels and reduces risk of CAD and CAVS, with PCSK9 present in calcified aortic valves and induced by oxidative stress.