Author

Masataka Kinjo

Hokkaido UniversityORCID 0000-0001-8889-8369Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Ai FujimotoiD· 1 shared Akira KitamuraiD· 1 shared Ayumi Kurata· 1 shared Kanami Moriya· 1 shared Kazuho Takahashi· 1 shared Kotetsu Sasaki· 1 shared Laura C. BottiD· 1 shared Rei KawashimaiD· 1 shared

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Molecular BiologyCommunications BiologyPeer-reviewedJun 20, 2024

Hetero-oligomerization of TDP-43 carboxy-terminal fragments with cellular proteins contributes to proteotoxicity

Akira Kitamura, Ai Fujimoto, Rei Kawashima…·Masataka Kinjo

This study shows that truncated RRM in TDP-43 CTFs causes structural changes in IDR, leading to toxic hetero-oligomers and cell-nonautonomous toxicity in nematodes.

15 citations

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