Author

Akira Kitamura

Hokkaido UniversityORCID 0000-0001-8357-8593Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Biophysics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1 Assay:fluorescence / live-cell microscopy· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

Ai FujimotoiD· 2 shared Kotetsu Sasaki· 2 shared Ayumi Kurata· 1 shared Haruki KawaiiD· 1 shared Kanami Moriya· 1 shared Kazuho Takahashi· 1 shared Laura C. BottiD· 1 shared Masataka KinjoiD· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersBiochemistry

Ai FujimotoORCID

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3 papers

Recent·Most cited

Optimizing automated detection for cytoplasmic TDP25 aggregates in fluorescence imaging

Sumire Sogawa, Kotetsu Sasaki, Akira Kitamura

This study improves automated detection of TDP25 aggregates in fluorescence images by reducing background noise and enhancing aggregate brightness, leading to better detection efficiency.

Spectroscopy Journal · May 19, 2025Peer-reviewedBiophysics

Spike protein of the SARS-CoV-2 omicron variant interacts with actin

Ai Fujimoto, Haruki Kawai, Rintaro Kawamura, Akira Kitamura

This study shows the Omicron variant's spike protein RBD binds more strongly to hACE2 and interacts with actin, suggesting potential changes in viral entry mechanisms.

Cells · Aug 7, 2024Peer-reviewedBiochemistry

Hetero-oligomerization of TDP-43 carboxy-terminal fragments with cellular proteins contributes to proteotoxicity

Akira Kitamura, Ai Fujimoto, Rei Kawashima, Yidan Lyu, Kotetsu Sasaki, Y. Hamada, Kanami Moriya, Ayumi Kurata, Kazuho Takahashi, Renée M. Brielmann, Laura C. Bott, Richard I. Morimoto, Masataka Kinjo

This study shows that truncated RRM in TDP-43 CTFs causes structural changes in IDR, leading to toxic hetero-oligomers and cell-nonautonomous toxicity in nematodes.

Communications Biology · Jun 20, 2024Peer-reviewedMolecular Biology