Author

Kotetsu Sasaki

Hokkaido University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Assay:fluorescence / live-cell microscopy· 1 Approach:microscopy & imaging analysis· 1

Frequent Co-Authors

Akira KitamuraiD· 2 shared Ai FujimotoiD· 1 shared Ayumi Kurata· 1 shared Kanami Moriya· 1 shared Kazuho Takahashi· 1 shared Laura C. BottiD· 1 shared Masataka KinjoiD· 1 shared Rei KawashimaiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersBiophysics

Akira KitamuraORCID

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2 papers

Recent·Most cited

Optimizing automated detection for cytoplasmic TDP25 aggregates in fluorescence imaging

Sumire Sogawa, Kotetsu Sasaki, Akira Kitamura

This study improves automated detection of TDP25 aggregates in fluorescence images by reducing background noise and enhancing aggregate brightness, leading to better detection efficiency.

Spectroscopy Journal · May 19, 2025Peer-reviewedBiophysics

Hetero-oligomerization of TDP-43 carboxy-terminal fragments with cellular proteins contributes to proteotoxicity

Akira Kitamura, Ai Fujimoto, Rei Kawashima, Yidan Lyu, Kotetsu Sasaki, Y. Hamada, Kanami Moriya, Ayumi Kurata, Kazuho Takahashi, Renée M. Brielmann, Laura C. Bott, Richard I. Morimoto, Masataka Kinjo

This study shows that truncated RRM in TDP-43 CTFs causes structural changes in IDR, leading to toxic hetero-oligomers and cell-nonautonomous toxicity in nematodes.

Communications Biology · Jun 20, 2024Peer-reviewedMolecular Biology