Margaret J. Lange

DUSP11 is an intracellular innate immune checkpoint in lung adenocarcinoma

This study identifies DUSP11 as an intracellular innate immune checkpoint in LUAD, showing its role in tumor survival and growth, and suggests it as a potential therapeutic target.

Differentiation SELEX approach identifies RNA aptamers with different specificities for HIV-1 capsid assembly forms

This study identifies RNA aptamers specific to different HIV-1 capsid assembly forms, enabling their purification from cell lysates without virus or host modification.

Activation of innate immune responses by a CpG oligonucleotide sequence composed entirely of threose nucleic acid.

The paper evaluates a threose nucleic acid (TNA) oligonucleotide derived from a CpG sequence and finds it induces immune responses in B cell lines with minimal effects on proliferation.

Poly-Target Selection Identifies Broad-Spectrum RNA Aptamers

The paper identifies broad-spectrum RNA aptamers that inhibit diverse primate lentiviral reverse transcriptases using a Poly-Target selection approach.