Author

John Charles Chaput

University of California, IrvineORCID 0000-0003-1393-135XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Synthetic Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Organism:human· 1

Frequent Co-Authors

Clement LopeziD· 1 shared Donald H. BurkeiD· 1 shared Eloi VincentiD· 1 shared Laurence A. MulardiD· 1 shared Marc Borie-Guichot· 1 shared Marc H. DelarueiD· 1 shared Marcel HollensteiniD· 1 shared Margaret J. LangeiD· 1 shared

Activity by Year

2018-2026 · peak 1/yr

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10 top collaborators · 29 mutual co-author links

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1 shared paperSynthetic Biology

Clement LopezORCID

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2 papers

Recent·Most cited

Synthetic BiologybioRxivPreprintJul 21, 2026

Polymerase Evolution Enables Access to Glycosylated Xeno-Nucleic Acids with Expanded Chemical Functionality

Eloi Vincent, Victoria A. Maola, Clement Lopez…·Marc H. Delarue

This paper evolves a DNA polymerase to synthesize glycosylated xeno-nucleic acids with base and backbone modifications, enabling new chemical functionality in genetic polymers.

DOI 10.64898/2026.07.20.739590

experimental assay

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Synthetic BiologyNucleic Acid TherapeuticsPeer-reviewedDec 11, 2018

Activation of innate immune responses by a CpG oligonucleotide sequence composed entirely of threose nucleic acid.

Margaret J. Lange, Donald H. Burke, John Charles Chaput

The paper evaluates a threose nucleic acid (TNA) oligonucleotide derived from a CpG sequence and finds it induces immune responses in B cell lines with minimal effects on proliferation.

19 citations

humanDNA methylation

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