Author

Laura M. Spring

Harvard UniversityORCID 0000-0001-8904-3514Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Laura M. Spring1 paper · Mass General Brigham

Biology Disciplines

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Cancer Biology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Approach:experimental assay· 1 Assay:imaging· 1 Assay:metabolomics· 1 Assay:proteomics· 1 Approach:statistical model· 1 Research Focus:trajectory inference· 1

Frequent Co-Authors

Adam Louis CoheniD· 1 shared Aditya BardiaiD· 1 shared Andrea H. BildiD· 1 shared Anne P. O’DeaiD· 1 shared Bryce OrdwayiD· 1 shared Chenxu GuoiD· 1 shared Eric F. ZaniewskiiD· 1 shared Esther RheinbayiD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperSystems Biology

Adam Louis CohenORCID

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2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintApr 9, 2026

A SIRT5-induced metabolic switch underlies chemoresistance and ATR checkpoint dependence in triple-negative breast cancer

Zuen Ren, Tiziano Bernasocchi, Kiran Kurmi…·Leif William Ellisen

This study identifies SIRT5-induced metabolic changes as a driver of chemoresistance in TNBC and reveals ATR checkpoint dependence as a therapeutic vulnerability.

DOI 10.64898/2026.04.07.716852

humanproteomics

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Systems BiologybioRxivPreprintJan 14, 2021

Reconstructing tumor trajectories during therapy through integration of multiple measurement modalities.

Jason I. Griffiths, Jinfeng Chen, Onalisa D. Winblad…·Qamar J. Khan

The paper reconstructs tumor size trajectories during therapy by integrating multiple measurement modalities to identify distinct patterns of tumor response and resistance.

2 citations

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