Jason I. Griffiths

Phylogenetic inference from single-cell RNA-seq data

PhylinSic reconstructs phylogenetic relationships from scRNA-seq data to model tumor evolution and identify subclones and lineage-specific gene expression patterns.

Ecological interactions in breast cancer: Cell facilitation promotes growth and survival under drug pressure

The paper shows that drug-sensitive breast cancer cells benefit from co-culture with resistant cells, which produce estradiol, leading to increased survival and resistance under treatment.

Reconstructing tumor trajectories during therapy through integration of multiple measurement modalities.

The paper reconstructs tumor size trajectories during therapy by integrating multiple measurement modalities to identify distinct patterns of tumor response and resistance.