Structural Mechanism and Cellular Restriction of Tau Seeding from Endolysosomes
Eric Herrmann, Shuixia Tan, Kevin M. Rose, Richard M. Hooy, James H. Hurley
This study investigates the role of lysosomal components in tau seeding and finds that the PITT pathway and VPS13C are strongly involved in tau spread, while CASM and ALG-2 have more limited roles.
bioRxiv · Jun 10, 2026 · PreprintCell Biology