Kevin M. Rose

Nanoscale remodeling of mitochondrial architecture duringmtRNA surveillance failure

The paper investigates how mitochondrial architecture changes during mtRNA surveillance failure, revealing stress body formation and spatial reorganization of mitochondrial components.

Fluorescent Biosensors for Cryogenic Correlative Light and Electron Microscopy

The paper develops fluorescent biosensors for cryogenic correlative light and electron microscopy to measure physiological conditions alongside structural data.

Structural Mechanism and Cellular Restriction of Tau Seeding from Endolysosomes

This study investigates the role of lysosomal components in tau seeding and finds that the PITT pathway and VPS13C are strongly involved in tau spread, while CASM and ALG-2 have more limited roles.

In situ cryo-ET visualization of mitochondrial depolarization and mitophagic engulfment

Cryo-ET of Parkin-expressing U2OS cells shows oligomycin/antimycin depolarization moves some ATP synthase to the inner boundary membrane, abolishes matrix calcium granules, and favors closed prohibitin domes.

Matters arising: Forced Symmetry Artifacts in a Prohibitin Complex Structure

The paper challenges a previously proposed structure of the prohibitin complex by showing that symmetry assumptions led to incorrect modeling of an asymmetric conformation.

Human ESCRT-I and ALIX function as scaffolding helical filaments in vivo

This study shows ESCRT-I and ALIX form helical filaments in vivo, serving as structural scaffolds and ESCRT-III assembly templates for membrane scission and viral budding.