MMP21 behaves as a fluid flow transported morphogen to impart laterality during development
Tim Ott, Amelie Brugger, Emmanuelle Szenker‐Ravi, Yvonne Kurrle, Olivia Aberle, Matthias Tisler, Martin Blum, Sandra Whalen, Patrice Bouvagnet, Bruno Reversade, Axel Schweickert
The paper identifies MMP21 as a morphogen transported by leftward fluid flow to specify left-sided development in Xenopus embryos, revealing its role in heterotaxy.
bioRxiv · Oct 13, 2024 · PreprintDevelopmental Biology