CRISPR/Cas9 targeting Ttc30a mimics ciliary chondrodysplasia with polycystic kidney disease.
Maike Getwan, Anselm Hoppmann, Pascal Schlosser, Kelli Grand, Weiting Song, Rebecca Diehl, Sophie Schroda, Florian Heeg, Konstantin Deutsch, Friedhelm Hildebrandt, Ekkehart U. Lausch, Anna Köttgen, Soeren S. Lienkamp
The paper identifies TTC30A/B as a key gene in ciliary chondrodysplasia and nephronophthisis-like disease using CRISPR/Cas9 in Xenopus tropicalis models.
Proceedings of the National Academy of Sciences · Sep 21, 2021Peer-reviewedDevelopmental Biology