Author

Bose S. Kochupurakkal

Brigham and Women's HospitalORCID 0000-0001-8929-3070Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Geoffrey Ira ShapiroiD· 2 shared Alan D. D’AndreaiD· 1 shared Astrid ZimmermanniD· 1 shared Changli Qian· 1 shared Elena V. IvanovaiD· 1 shared Erica M. HoldridgeiD· 1 shared Gordon James FreemaniD· 1 shared Gregory Michael CoteiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersCancer Biology

Geoffrey Ira ShapiroORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintOct 28, 2026

DNA-PK enforces the S/G2 checkpoint in ATM-deficient cells to limit ATR inhibitor efficacy

Timothy B. Branigan, Roshen Alharthi, Bose S. Kochupurakkal…·Geoffrey Ira Shapiro

This study shows DNA-PK enforces the S/G2 checkpoint in ATM-deficient cells, reducing ATR inhibitor efficacy, and suggests combining ATR and DNA-PK inhibition could enhance treatment in such cancers.

DOI 10.64898/2026.10.25.761677

humanexperimental assay

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Cancer BiologyNature CommunicationsPeer-reviewedMay 4, 2026

Targeting FGFR signaling overcomes therapeutic resistance and immune evasion in oncogenic PIK3CA-driven serous-like endometrial cancer

Xin Cheng, Y Zhang, Changli Qian…·Jean J. Zhao

This study identifies FGFR signaling as a driver of resistance and immune evasion in PIK3CA-driven serous-like endometrial cancer and shows that dual FGFR/PI3K inhibition improves tumor control.

DOI 10.1038/s41467-026-72544-z

mousebulk RNA-seq

𝕏 PostBluesky