Author

Y Zhang

Boston Children's Hospital

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Same name, identified by ORCID

Biology Disciplines

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Cancer Biology· 2 Genetic & Genomic Medicine· 1 Genomics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:statistical model· 3 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

Adolf PfefferbaumiD· 1 shared Adriana MiglioriniiD· 1 shared Amirthagowri AmbalavananiD· 1 shared Amy Xin Wei ZhangiD· 1 shared Andreas MundiD· 1 shared Anirban MaitraiD· 1 shared Anna DoddiD· 1 shared Ayah Elqaderi· 1 shared

Activity by Year

2021-2026 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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1 shared paperNeuroscience

Adolf PfefferbaumORCID

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Droplet-compatible single-cell DNA methylation sequencing with PreTIC

Sheng Zhang, Faming Wang, Y Zhang, Keng-Jung Lee, Carl Engman, Hong-Zhang He, Yong Fan, Si-Yang Zheng

The paper introduces PreTIC, a method for single-cell DNA methylation sequencing compatible with droplet microfluidics, and demonstrates its ability to generate over 13,000 methylomes from human cells.

bioRxiv · Jun 21, 2026 · PreprintGenomics

Epistatic SNP network analysis (ESNA): A scalable framework for genome-wide detection of higher-order genetic interactions

Y Zhang, Ming Han, Amirthagowri Ambalavanan, Danai Georgia Topouza, Zhi Yi Fang, Sara A Stickley, Shrey Anand, Stuart E. Turvey, Piush J. Mandhane, Elinor Simons, Theo J. Moraes, Padmaja Subbarao, Jihoon Choi, Qingling Duan

ESNA detects higher-order genetic interactions using genome-wide SNP data, identifying 914 SNP network modules associated with respiratory outcomes in children.

medRxiv · May 13, 2026 · PreprintGenetic & Genomic Medicine

Extra-lineage tissue programs define the transcription states of human pancreatic cancer

Sabrina Ge, Paul Tonon, Jingxiong Xu, Gun-Ho Jang, Ferris Nowlan, Jimin Min, Karen Ng, Eugenia Flores Figueroa, Amy Xin Wei Zhang, Michelle Chan‐Seng‐Yue, Yuanchang Fang, Adriana Migliorini, Julie M. Wilson, Anna Dodd, Sebastian Arcila-Barrera, , Faiyaz Notta

The paper identifies four epithelial transcription states in pancreatic cancer and links their origins to early developmental processes.

bioRxiv · May 4, 2026 · PreprintCancer Biology

Targeting FGFR signaling overcomes therapeutic resistance and immune evasion in oncogenic PIK3CA-driven serous-like endometrial cancer

Xin Cheng, Y Zhang, Changli Qian, Erica M. Holdridge, Guruprasad Ananda, Tao Jiang, Jing Ni, Shaozhen Xie, Hao Gu, Renlei Ji, Elena V. Ivanova, Marisa R. Nucci, Zhe Wang, Kaifu Chen, Bose S. Kochupurakkal, , Jean J. Zhao

This study identifies FGFR signaling as a driver of resistance and immune evasion in PIK3CA-driven serous-like endometrial cancer and shows that dual FGFR/PI3K inhibition improves tumor control.

Nature Communications · May 4, 2026Peer-reviewedCancer Biology

Adolescent Binge Drinking is Associated with Accelerated Decline of Gray Matter Volume

Maria Alejandra Infante, Sonja Eberson, Y Zhang, Ty Brumback, Sandra A. Brown, Ian M. Colrain, Fiona C. Baker, Duncan B. Clark, Michael D. De Bellis, David B. Goldston, Bonnie J. Nagel, Kate Brody Nooner, Qingyu Zhao, Kilian M. Pohl, Edith V. Sullivan, , Wesley Kurt Thompson

This study examines how binge drinking affects gray matter volume decline in adolescents over time, finding stronger effects in younger individuals and suggesting potential for recovery with temporally proximal drinking.

Cerebral Cortex · Sep 13, 2021Peer-reviewedNeuroscience