Author

Gordon James Freeman

Harvard UniversityORCID 0000-0002-7210-5616Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:mouse· 2 Approach:benchmark study· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Akil AkhtariD· 1 shared Amy Y. HuangiD· 1 shared Anish SuriiD· 1 shared Arlene H. SharpeiD· 1 shared Bose S. KochupurakkaliD· 1 shared Cassia Wang· 1 shared Changli Qian· 1 shared Cora A. RickeriD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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1 shared paperImmunology

Akil AkhtarORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

ImmunologyJournal of VirologyPeer-reviewedJun 15, 2026

Simultaneous TCR and IL-2 agonism selectively enhances epitope-specific CD8 T cell responses during chronic viral infection

Masao Hashimoto, Mohammad Affan Khan, Akil Akhtar…·Rafi Ahmed

This study shows that targeting IL-2 to antigen-specific CD8 T cells enhances their responses during chronic viral infection while sparing non-targeted populations, and combining this with PD-1 blockade further improves outcomes.

DOI 10.1128/jvi.00593-26

mouseexperimental assay

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Cancer BiologyNature CommunicationsPeer-reviewedMay 4, 2026

Targeting FGFR signaling overcomes therapeutic resistance and immune evasion in oncogenic PIK3CA-driven serous-like endometrial cancer

Xin Cheng, Y Zhang, Changli Qian…·Jean J. Zhao

This study identifies FGFR signaling as a driver of resistance and immune evasion in PIK3CA-driven serous-like endometrial cancer and shows that dual FGFR/PI3K inhibition improves tumor control.

DOI 10.1038/s41467-026-72544-z

mousebulk RNA-seq

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Cancer BiologybioRxivPreprintOct 29, 2024

Stratified analysis identifies HIF-2α as a therapeutic target for highly immune-infiltrated melanomas

Amy Y. Huang, Kelly P. Burke, Ryan M. Porter…·David Liu

The paper identifies HIF-2α as a therapeutic target for immune-infiltrated melanomas through stratified analysis of clinical and molecular data.

3 citations

humanbulk RNA-seq

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