Heidi E. Klumpe

This study shows that synthetic cell-cell adhesion in yeast allows large aggregates to grow as well as unicellular strains, suggesting benefits from nutrient sharing rather than diffusion limitations.

This paper uses deep neural networks to predict single-cell responses and probability landscapes, showing they can infer cell dynamics despite noise and stochasticity.

The paper develops a mathematical model to show how promiscuous ligand-receptor interactions enable efficient cellular addressing through combinatorial signaling.

The paper investigates how BMP ligands interact combinatorially and context-dependently through receptor expression, revealing equivalence groups and a biochemical model for signaling complex formation.