Cancer BiologyJCI InsightPeer-reviewed
Epithelial HO-1 regulates iron availability and promotes colonic tumorigenesis in a context-dependent manner
Rosemary C. Callahan, Jillian Curry, Geetha Bhagavatula…·Joseph C. Onyiah
This study shows that epithelial HO-1 promotes colonic tumorigenesis in chronic inflammation by increasing iron availability and oxidative stress, while protecting against acute heme toxicity.