Jeffrey L. Cummings

Single-cell digital twins identify drug targets and repurposable medicine in Alzheimers disease

This study develops a single-cell digital twin framework to identify drug targets and repurposable medicines in Alzheimer's disease using single-nuclei RNA-seq and ATAC-seq data.

Genetic correlations between gut microbiota genera and Alzheimers Disease

The paper identifies nine gut microbiota genera genetically correlated with Alzheimer's disease and links some to the APOE rs429358 risk allele.

Multimodal single-cell/nucleus RNA-sequencing data analysis uncovers molecular networks between disease-associated microglia and astrocytes with implications for drug repurposing in Alzheimer's disease

AlzGPS: A Genome-wide Positioning Systems Platform to Catalyze Multi-omics for Alzheimer's Therapeutic Discovery

AlzGPS integrates multi-omics data and networks to identify repurposable drugs for Alzheimer's disease.