Jielin Xu

Dysregulation of innate immunity and cellular metabolism through virus-induced deISGylation

This study shows that SARS-CoV-2 deISGylation by PLpro suppresses innate immunity and promotes viral replication by modulating cellular metabolism.

Network medicine informed multi-omics integration identifies drug targets and repurposable medicines for Amyotrophic Lateral Sclerosis

This study integrates multi-omics data using network medicine to identify potential drug targets and repurposable treatments for ALS.

Alzheimer's disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy model

This study combines APOE4 and TREM2R47H in female tauopathy mice to identify pathways activated by AD risk factors, finding cGAS-STING signaling and microglial senescence as potential drivers.

Comprehensive characterization of multi-omic landscapes between gut-microbiota metabolites and the G-protein-coupled receptors in Alzheimer's disease

This study identifies GPCR targets of gut microbiota metabolites in Alzheimer's disease using multi-omics and machine learning.

Single-cell network biology characterizes cell-type gene regulation for drug repurposing and phenotype prediction in Alzheimer's disease

The paper uses single-cell multi-omics data to predict gene regulatory networks in Alzheimer's disease and control, identifying cell-type-specific dysregulation and potential drug targets.

A Network-based Deep Learning Framework Catalyzes GWAS and Multi-Omics Findings to Biology and Drug Repurposing for Alzheimer's Disease

This paper introduces a network-based deep learning framework to translate GWAS findings into biological insights and drug targets for Alzheimer's disease, identifying 156 putative risk genes.

Network medicine links SARS-CoV-2/COVID-19 infection to brain microvascular injury and neuroinflammation in dementia-like cognitive impairment

This study links SARS-CoV-2 infection to brain microvascular injury and neuroinflammation in dementia-like cognitive impairment through network-based genomics analysis.

Multimodal single-cell/nucleus RNA-sequencing data analysis uncovers molecular networks between disease-associated microglia and astrocytes with implications for drug repurposing in Alzheimer's disease

A Signaling Network based Computational Model to Uncover Loop as the Novel Molecular Mechanisms for Medulloblastoma

This study develops a signaling network model to identify loop sub-structures in PPI networks that predict drug resistance in medulloblastoma subtypes.