A single-domain antibody targets aggregation-prone region of α-synuclein to reduce synucleinopathy, rescue neurodegeneration and improve function
Pragati, Erin E. Congdon, Yixiang Jiang…·Einar M. Sigurdsson
This study evaluates five anti-α-synuclein single-domain antibodies in Drosophila models, identifying 2H1 as the most effective in reducing pathology and improving disease parameters.