Yixiang Jiang

This study evaluates five anti-α-synuclein single-domain antibodies in Drosophila models, identifying 2H1 as the most effective in reducing pathology and improving disease parameters.

This paper presents a single-domain antibody-based protein degrader that reduces tau levels and improves motor function in tauopathy models.

This study investigates neuronal function and network activity in early-stage tauopathy mice, finding hypofunction in motor cortical neurons and partial restoration with tau antibody treatment.

The paper evaluates the accuracy of polygenic risk scores for MDD in African ancestry UK Biobank participants using European and African GWAS data, finding lower predictive power from European-derived PRS.

This paper develops a single-domain antibody-based protein degrader that enhances proteasomal and lysosomal degradation of α-synuclein in synucleinopathy models.