Author

Thomas C. Williams

Commonwealth Scientific and Industrial Research OrganisationORCID 0000-0002-0594-3441Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Synthetic Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:yeast· 2 Research Focus:benchmarking· 1 Research Focus:database / resource· 1 Assay:DNA methylation· 1 Research Focus:variant calling· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Ian T. PaulseniD· 2 shared Isak S. PretoriusiD· 2 shared Monica I. EspinosaiD· 2 shared Alexander C. CarpenteriD· 1 shared Anthony R. BornemaniD· 1 shared Briardo LlorenteiD· 1 shared Colin ScottiD· 1 shared Daniel L. JohnsoniD· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersSynthetic Biology

Ian T. PaulsenORCID

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2 papers

Recent·Most cited

Laboratory evolution and polyploid SCRaMbLE reveal genomic plasticity to synthetic chromosome defects and rearrangements

Thomas C. Williams, Heinrich Kroukamp, Xin Xu, Elizabeth L. I. Wightman, Briardo Llorente, Anthony R. Borneman, Alexander C. Carpenter, Niël van Wyk, Monica I. Espinosa, Elizabeth L. Daniel, Roy S. K. Walker, Yizhi Cai, Helena K. M. Nevalainen, Natalie C. Curach, Ira W. Deveson, , Ian T. Paulsen

The paper debugs a synthetic yeast chromosome and uses laboratory evolution to identify genomic rearrangements that suppress growth defects caused by synthetic modifications.

bioRxiv · Jul 22, 2022 · PreprintSynthetic Biology

Engineering and Evolution of Methanol Assimilation in Saccharomyces cerevisiae

Monica I. Espinosa, R. Axayácatl González-García, Kaspar Valgepea, Manuel R. Plan, Colin Scott, Isak S. Pretorius, Esteban Marcellin, Ian T. Paulsen, Thomas C. Williams

This paper engineers methanol assimilation pathways in yeast and identifies a latent methylotrophic metabolism, improving growth and metabolite labeling through genetic modifications.

bioRxiv · Feb 16, 2020 · PreprintSynthetic Biology