Gayun Bu

smDeepFLUOR uses deep learning to classify single-molecule fluorescence signals, distinguishing specific from nonspecific protein binding with 97% accuracy and capturing DNA synthesis kinetics.

This study shows PAF15 stabilizes PCNA on DNA, slows its sliding, and regulates its loading/unloading, impacting genome stability.

This study shows that molecular motion enhances signal-to-noise ratio in single-molecule fluorescence imaging and proposes a method to increase the upper concentration limit of fluorophore-tagged biomolecules.