Jong‐Bong Lee

smDeepFLUOR uses deep learning to classify single-molecule fluorescence signals, distinguishing specific from nonspecific protein binding with 97% accuracy and capturing DNA synthesis kinetics.

This study shows tau protein binds DNA, forms condensates, and localizes to centromeres, suggesting a new role in mitosis and cell division.

This study shows PAF15 stabilizes PCNA on DNA, slows its sliding, and regulates its loading/unloading, impacting genome stability.

This paper introduces a deep-learning method to predict spatially varying bending stiffness of biopolymers, showing high accuracy and revealing stiffness variations in filopodia and microtubules.

The paper introduces a surface-free single-molecule blotting platform called DNA Hanger that reduces nonspecific binding and improves sensitivity for detecting sub-picomolar concentrations of fluorophore-conjugated proteins.

This study shows that molecular motion enhances signal-to-noise ratio in single-molecule fluorescence imaging and proposes a method to increase the upper concentration limit of fluorophore-tagged biomolecules.