A. Catherine Pearson

The NOX2-ROS-NLRP3 inflammasome axis in traumatic brain injury

This paper investigates the role of NOX2-ROS-NLRP3 inflammasome axis in traumatic brain injury and shows that inhibiting NOX2 with GSK2795039 reduces neuroinflammation and improves neurobehavioral outcomes in mice.

Beta-Hydroxybutyrate but not NMN supplementation mimics caloric restriction reducing early mortality in Daphnia

The paper tests if BHB or NMN can mimic caloric restriction in Daphnia, finding BHB reduces early mortality similar to CR, while NMN does not and may negate BHB's effects.

Ketone body b-Hydroxybutyrate does not extend lifespan, but upregulates fecundity in food-limited Daphnia, with a transgenerational effect

This study shows that b-hydroxybutyrate reduces lifespan but increases fecundity in Daphnia magna, with a transgenerational effect dependent on genotype.

Post-senescence reproductive rebound in Daphnia associated with reversal of age-related transcriptional changes

The paper analyzes RNAseq data from Daphnia magna to show that post-senescence reproductive events involve reversal of age-related transcriptional changes, suggesting potential mechanisms for reproductive rejuvenation.