David J. Loane

This study investigates how innate immune activation, particularly IL-1β, affects T cell dynamics and functional recovery after traumatic brain injury in mice.

This paper investigates the role of NOX2-ROS-NLRP3 inflammasome axis in traumatic brain injury and shows that inhibiting NOX2 with GSK2795039 reduces neuroinflammation and improves neurobehavioral outcomes in mice.

This study uses high-dimensional proteomic analysis to identify TBI-specific plasma protein changes linked to injury patterns and pathophysiology in humans.

This study reviews preclinical blood biomarkers for traumatic brain injury, finding that NfL and GFAP show promise for prognosis and pharmacodynamic studies.

This study shows that brain injury accelerates age-related microglial changes linked to hyperphagocytosis and neurodegeneration in old mice.

The paper investigates how region-specific homeostatic identities of astrocytes influence their reactive phenotypes across different pathological insults.

This study shows that removing microglia with a CSF1R inhibitor after TBI reduces neurodegeneration and improves neurological outcomes.